双相情感障碍患者中风风险是否增加？一项系统评价和荟萃分析。
Do patients with bipolar disorders have an increased risk of stroke? A systematic review and meta-analysis.
作者信息
Guo Lingli, Wu Fanghua, Yang Jiaojiao
机构信息
Lingli Guo, Department of Psychosomatic Disorders, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang Province 313000, P.R. China.
Fanghua Wu, Department of Psychosomatic Disorders, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, Huzhou, Zhejiang Province 313000, P.R. China.
出版信息
Pak J Med Sci. 2024 Dec;40(11):2739-3745. doi: 10.12669/pjms.40.11.10732.
OBJECTIVE
The objective of the current review aimed to assess if patients with bipolar disorder (BD) have an increased risk of stroke.
METHODS
A literature search was conducted on PubMed, Embase, ScienceDirect, and Web of Science for studies published from inception to 20 June 2023 and reporting the association between BD and stroke.
RESULTS
Eight studies with 9187894 participants were eligible. Meta-analysis of all eight studies demonstrated that BD patients have an increased risk of stroke as compared to non-BD individuals (HR: 1.60 95% CI: 1.24, 2.05 I=94%). Results did not change in significance on sensitivity analysis. However, results varied on subgroup analysis based on study location, study type, sample size, and follow-up duration. The effect magnitude was unchanged based on the adjustment of diabetes and hypertension and study quality.
CONCLUSION
Patients with bipolar disorder (BD) may have an increased risk of stroke in comparison to the general population. The results are limited by the retrospective nature of the data and high inter-study heterogeneity which demand caution in the interpretation of the outcomes. PROSPERO (CRD42023434365), https://www.crd.york.ac.uk/prospero/.
目的
本综述旨在评估双相情感障碍（BD）患者是否具有更高的中风风险。
方法
在PubMed、Embase、ScienceDirect和Web of Science上进行文献检索，查找自数据库建立至2023年6月20日发表的、报告BD与中风之间关联的研究。
结果
八项研究符合纳入标准，共涉及9187894名参与者。对所有八项研究进行的荟萃分析表明，与非BD个体相比，BD患者发生中风的风险更高（风险比：1.60；95%置信区间：1.24，2.05；I² = 94%）。敏感性分析结果在显著性上没有变化。然而，基于研究地点、研究类型、样本量和随访持续时间的亚组分析结果有所不同。根据糖尿病和高血压的调整以及研究质量，效应大小没有变化。
结论
与普通人群相比，双相情感障碍（BD）患者可能具有更高的中风风险。这些结果受到数据回顾性性质和研究间高度异质性的限制，在解释结果时需谨慎。PROSPERO（CRD42023434365），https://www.crd.york.ac.uk/prospero/ 。
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