Spoov J, Bredbacka P E, Appelberg B, Katila H, Karonen S L, Rimón R, Sarna S
Department of Psychiatry, University of Helsinki, Finland.
Biol Psychiatry. 1991 Feb 1;29(3):204-10. doi: 10.1016/0006-3223(91)91282-v.
Nonaffective psychotic symptoms are heterogeneous and probably caused by mixed biopathology. A preliminary investigative tool to study pituitary dopamine activity, the prolactin response to submaximal stimulation by thyrotropin-releasing hormone (TRH) (mini-TRH test) was correlated in 20 subjects with nonaffective psychoses to positive psychotic symptoms as assessed by the Comprehensive Psychiatric Rating Scale psychosis subscale. A significant positive correlation was observed between the response and ratings of nonparanoid symptoms, especially nonparanoid delusions and disrupted thoughts. Because, in addition to pituitary dopamine activity, there is evidence to suggest that the response reflects extrapituitary dopamine activity as well, the results extend the evidence that nonparanoid acute productive psychotic symptoms may be associated with hypoactivity rather than with hyperactivity of brain dopaminergic systems.
非情感性精神病症状具有异质性，可能由混合性生物病理学原因引起。作为一种研究垂体多巴胺活性的初步调查工具，促甲状腺激素释放激素（TRH）对次最大刺激的催乳素反应（迷你TRH试验）在20名患有非情感性精神病的受试者中，与综合精神病评定量表精神病分量表评估的阳性精神病症状相关。在该反应与非偏执症状的评分之间观察到显著正相关，尤其是非偏执性妄想和思维紊乱。由于除垂体多巴胺活性外，有证据表明该反应也反映垂体外多巴胺活性，因此这些结果扩展了以下证据：非偏执性急性幻觉症性精神病症状可能与脑多巴胺能系统的功能减退而非功能亢进有关。
