Sharma J B, Sharma A, Bahadur A, Vimala N, Satyam A, Mittal S
Department of Obstetrics and Gynaecology, All-India Institute of Medical Sciences, New Delhi, India.
Int J Gynaecol Obstet. 2006 Jul;94(1):23-7. doi: 10.1016/j.ijgo.2006.03.025. Epub 2006 May 30.
To compare the levels of 3 oxidative stress markers (glutathione peroxidase [GPX], superoxide dismutase [SOD], and malondialdehyde [MDA]) and 2 antioxidants (vitamin C and lycopene) in healthy and pre-eclamptic pregnant women.
Circulating levels of GPX, SOD, MDA, vitamin C and lycopene were measured in 50 healthy pregnant women and 50 women with pre-eclampsia (PE) (41 with mild PE and 9 with severe PE) attending the antenatal clinic or admitted to the maternity ward of the All-India Institute of Medical Sciences, New Delhi, India.
The levels of GPX, SOD and MDA were significantly higher in women with PE than in controls, and the increase was higher in women with severe PE (P<0.001 using analysis of variance and the Kruskal Wallis test). The levels of vitamin C and lycopene were significantly lower in women with PE than in controls, with a greater decrease in women with severe PE.
Increased levels of oxidative stress markers and decreased levels of antioxidants in pre-eclamptic women suggest that oxidative stress markers play a significant role in the pathophysiology of pre-eclampsia, and that supplemental dietary antioxidants may have a beneficial role in the prevention of pre-eclampsia in women at high-risk for this condition.
比较健康孕妇和子痫前期孕妇体内3种氧化应激标志物（谷胱甘肽过氧化物酶[GPX]、超氧化物歧化酶[SOD]和丙二醛[MDA]）以及2种抗氧化剂（维生素C和番茄红素）的水平。
在印度新德里全印医学科学研究所产前诊所就诊或入住产科病房的50名健康孕妇和50名单纯收缩期高血压孕妇（41名轻度单纯收缩期高血压患者和9名重度单纯收缩期高血压患者）中，检测循环中GPX、SOD、MDA、维生素C和番茄红素的水平。
子痫前期孕妇体内GPX、SOD和MDA的水平显著高于对照组，且重度子痫前期孕妇升高更明显（方差分析和Kruskal Wallis检验，P<0.001）。子痫前期孕妇体内维生素C和番茄红素的水平显著低于对照组，重度子痫前期孕妇下降更明显。
子痫前期孕妇氧化应激标志物水平升高，抗氧化剂水平降低，提示氧化应激标志物在子痫前期病理生理过程中起重要作用，补充膳食抗氧化剂可能对预防高危子痫前期孕妇子痫前期有有益作用。
