Sainsbury R S, Partlo L A
Department of Psychology, University of Calgary, Alberta, Canada.
Brain Res Bull. 1991 Jan;26(1):37-42. doi: 10.1016/0361-9230(91)90189-q.
The alpha 2 agonists detomidine and xylazine were given to freely moving rats implanted with bilateral hippocampal recording electrodes. These alpha 2 agonists produced virtually continuous type 2 (immobility) theta. Type 1 (movement) theta was attenuated with these drugs. Subsequent administration of atropine sulfate eliminated all theta in the hippocampus. Other animals were given the alpha 2 antagonist tolazoline. This drug had no effect on type 1 theta but animals showed an increase in the production of type 2 theta during sensory stimulation. These type 2 theta responses habituated both within and between trials. Tolazoline was ineffective as a blocking agent for the effects of detomidine. Preadministration of atropine sulfate blocked the effects of detomidine on type 2 theta but not on the elimination of type 1 theta. Results are discussed in terms of alpha 2 modulation of the cholinergic and serotonergic systems.
将α2激动剂地托咪定和赛拉嗪给予双侧海马植入记录电极的自由活动大鼠。这些α2激动剂几乎产生持续的2型（不动）θ波。1型（运动）θ波被这些药物减弱。随后给予硫酸阿托品消除了海马中的所有θ波。其他动物给予α2拮抗剂托拉唑啉。这种药物对1型θ波没有影响，但动物在感觉刺激期间2型θ波的产生增加。这些2型θ波反应在试验内和试验间都出现了习惯化。托拉唑啉作为地托咪定作用的阻断剂无效。预先给予硫酸阿托品可阻断地托咪定对2型θ波的作用，但不能阻断1型θ波的消除。根据α2对胆碱能和5-羟色胺能系统的调节对结果进行了讨论。
