P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.
作者信息
Arasappan Ashok, Njoroge F George, Chen Kevin X, Venkatraman Srikanth, Parekh Tejal N, Gu Haining, Pichardo John, Butkiewicz Nancy, Prongay Andrew, Madison Vincent, Girijavallabhan Viyyoor
机构信息
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
出版信息
Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. doi: 10.1016/j.bmcl.2006.05.022. Epub 2006 May 30.
PMID:16730985
Abstract
Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.
摘要
Zotero 插件