某些药物对杜氏利什曼原虫前鞭毛体的体外疗效。

In vitro efficacy of some drugs on promastigotes of Leishmania donovani.

作者信息

Al-Khateeb G H, Al-Jeboori T I, Al-Janabi K A

出版信息

Chemotherapy. 1977;23(4):267-75. doi: 10.1159/000221994.

DOI:10.1159/000221994

Abstract

Sodium stibogluconate, metronidazole and dehydroemetine Roche were tested for their in vitro action on the mobility, morphology and survival of promastigotes of Leishmania donovani. At low concentrations, sodium stibogluconate, the drug of choice for kala azar treatment in Iraq proved to be poorly effective in the prevention of promastigotes growth in vitro. On the other hand, both metronidazole and dehydroemetine Roche at low concentrations were highly effective in the prevention of promastigotes of L. donovani growth in vitro. 3.51 X 10(2), 9.34 and 3.13 mmol of sodium stibogluconate, metronidazole and dehydroemetine, respectively, were required to show the same effect in vitro.

摘要

对葡萄糖酸锑钠、甲硝唑和去氢吐根碱罗氏盐进行了体外试验，观察它们对杜氏利什曼原虫前鞭毛体的运动性、形态和存活的影响。在低浓度下，葡萄糖酸锑钠是伊拉克治疗黑热病的首选药物，但在体外预防前鞭毛体生长方面效果不佳。另一方面，低浓度的甲硝唑和去氢吐根碱罗氏盐在体外预防杜氏利什曼原虫前鞭毛体生长方面非常有效。分别需要3.51×10²、9.34和3.13毫摩尔的葡萄糖酸锑钠、甲硝唑和去氢吐根碱才能在体外显示相同的效果。