Aimone James B, Wiles Janet, Gage Fred H
Laboratory of Genetics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Nat Neurosci. 2006 Jun;9(6):723-7. doi: 10.1038/nn1707.
The dentate gyrus in the hippocampus is one of two brain regions with lifelong neurogenesis in mammals. Despite an increasing amount of information about the characteristics of the newborn granule cells, the specific contribution of their robust generation to memory formation by the hippocampus remains unclear. We describe here a possible role that this population of young granule cells may have in the formation of temporal associations in memory. Neurogenesis is a continuous process; the newborn population is only composed of the same cells for a short period of time. As time passes, the young neurons mature or die and others are born, gradually changing the identity of this young population. We discuss the possibility that one cognitive impact of this gradually changing population on hippocampal memory formation is the formation of the temporal clusters of long-term episodic memories seen in some human psychological studies.
海马体中的齿状回是哺乳动物中两个具有终身神经发生的脑区之一。尽管关于新生颗粒细胞特征的信息越来越多，但它们大量生成对海马体记忆形成的具体贡献仍不清楚。我们在此描述了这群年轻颗粒细胞在记忆中时间关联形成中可能具有的作用。神经发生是一个持续的过程；新生群体在短时间内仅由相同的细胞组成。随着时间的推移，年轻神经元成熟或死亡，其他神经元诞生，逐渐改变了这群年轻细胞的特性。我们讨论了这种逐渐变化的群体对海马体记忆形成的一种认知影响是在一些人类心理学研究中看到的长期情景记忆时间簇的形成的可能性。
