Whitfield James F, Chakravarthy Balu R
Molecular Signalling Group, National Research Council, Institute for Biological Sciences, ON, Canada.
Cell Signal. 2009 Sep;21(9):1351-5. doi: 10.1016/j.cellsig.2009.02.013. Epub 2009 Feb 26.
Considerable attention has recently been focused on the postnatal persistence of neurogenesis in the dentate gyrus of the hippocampus and the roles of signals from the primary cilium in the different functions of an increasing number of tissues and their malfunctions. Here we summarize the evidence that ties sonic hedgehog-triggered proliferogenic signaling from the primary cilia on granule cell progenitors in the adult dentate subgranular zone to maintain a pool of new "blank slate" dentate granule cells. These can be recruited to bundle and encode novel inputs flowing from various regions of the brain into the dentate gyrus via the entorhinal cortex without altering and erasing the synaptic patterns from previous inputs inscribed on older granule cells.
最近，相当多的注意力集中在海马齿状回中神经发生的产后持续性，以及初级纤毛发出的信号在越来越多组织的不同功能及其功能障碍中所起的作用。在这里，我们总结了相关证据，这些证据将成年齿状回颗粒细胞祖细胞上初级纤毛发出的音猬因子触发的增殖信号联系起来，以维持一群新的“白板”齿状颗粒细胞。这些细胞可以被招募来捆绑并编码从大脑各个区域通过内嗅皮质流入齿状回的新输入信号，而不会改变和擦除刻写在较老颗粒细胞上的先前输入信号的突触模式。
