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从菠萝蜜中分离出的类异戊二烯取代黄酮对黑色素生物合成的抑制作用。

Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis.

作者信息

Arung Enos Tangke, Shimizu Kuniyoshi, Kondo Ryuichiro

机构信息

Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

出版信息

Planta Med. 2006 Jul;72(9):847-50. doi: 10.1055/s-2006-931606. Epub 2006 May 29.

DOI:10.1055/s-2006-931606
PMID:16732541
Abstract

Isoprenoid-substituted flavonoids were isolated from the wood of Artocarpus heterophyllus by means of activity-guided fractionation. Artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5) and albanin A (6) inhibited melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. A structure-activity investigation indicated that the presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells.

摘要

通过活性导向分级分离法从菠萝蜜木材中分离出类异戊二烯取代的黄酮类化合物。菠萝蛋白酶（1）、柘树黄酮C（2）、6-异戊烯基芹菜素（3）、库瓦诺酮C（4）、去甲菠萝蛋白酶（5）和阿尔巴宁A（6）在不抑制酪氨酸酶的情况下抑制B16黑色素瘤细胞中的黑色素生物合成。结构-活性研究表明，类异戊二烯取代部分的存在增强了对B16黑色素瘤细胞中黑色素生成的抑制活性。

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