Ninfo V, Pezzuoli G, Piazza M, Roviaro G
Minerva Chir. 1975 May 31;30(10):592-601.
Bilateral breast cancer is examined in the light of the literature data and a personal series. Lobular, asynchronous forms, either in situ or infiltrating, are usually involved. The fact that in situ changes are often found in the second neoplasia, with metastases solely in its tributary lymph nodes, suggests that such carcinoma was already present at the time of the first operation, though not clinically detectable. Since bilateral forms are commonly hormone-dependent, multiple biopsies should be routine on the contralateral breast. Preventive mastectomy associated with ovariectomy shold be performed on the slightest sign of carcinomatous or even precancerous alterations.
根据文献数据和个人病例系列对双侧乳腺癌进行了研究。小叶型、不同时发生的原位或浸润性癌通常会累及。在第二个肿瘤中经常发现原位改变,且转移仅局限于其引流淋巴结,这一事实表明,这种癌在首次手术时就已存在,尽管临床上无法检测到。由于双侧乳腺癌通常依赖激素,因此对侧乳房进行多次活检应成为常规操作。一旦出现癌变甚至癌前病变的最轻微迹象,就应进行预防性乳房切除术并辅以卵巢切除术。