Li Jin-fan, Liu Wei-ping, Li Gan-di, Tang Yuan, Liao Dian-ying
Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China.
Zhonghua Xue Ye Xue Za Zhi. 2006 Jan;27(1):36-41.
To evaluate pathomorphologic and immunohistochemical characteristics of the bone marrow involvement of lymphoma and its significance in the diagnosis and subtype of lymphoma with bone marrow involvement.
One hundred and eighty eight formalin fixed and paraffin embedded bone marrow biopsy specimens were studied. Immunohistochemical staining was performed.
(1) Five patterns of bone marrow involvement of lymphoma were found, including diffuse (44.9%), focal (29.3%), interstitial (11.6%) and nodular (6.1%). (2) There were many subtypes of lymphoma in these cases, the most common type was lymphoplasmacytic lymphoma (21.7%). (3) The lymphomas in bone marrow biopsy had their own special characteristics of morphology and immunophenotype as did in extra-medullar lymphomas. (4) Fibrosis (75.8%) and hematopoietic tissue hypoplasia (71.1%) were found in most cases and necrosis in a few cases.
Most cases of bone marrow involvement of lymphoma could be diagnosed and classified by combination of histopathological and immunohistochemical analysis. Diagnosis of some cases could be made only after the review of pathological changes of lymph node. A few cases were difficult to classify their subtypes of lymphoma.
评估淋巴瘤骨髓受累的病理形态学及免疫组化特征，及其在诊断和伴有骨髓受累的淋巴瘤亚型方面的意义。
研究188例经福尔马林固定、石蜡包埋的骨髓活检标本，进行免疫组化染色。
（1）发现淋巴瘤骨髓受累有5种模式，包括弥漫型（44.9%）、局灶型（29.3%）、间质型（11.6%）和结节型（6.1%）。（2）这些病例中有多种淋巴瘤亚型，最常见的类型是淋巴浆细胞性淋巴瘤（21.7%）。（3）骨髓活检中的淋巴瘤与髓外淋巴瘤一样，具有其自身特殊的形态学和免疫表型特征。（4）大多数病例发现有纤维化（75.8%）和造血组织发育不全（71.1%），少数病例有坏死。
多数淋巴瘤骨髓受累病例可通过组织病理学和免疫组化分析相结合进行诊断和分型。部分病例仅在复查淋巴结病理改变后才能确诊。少数病例难以明确淋巴瘤的亚型。
