Boulet Louis-Philippe
Hôpital Laval, Centre de Pneumologie, Sainte-Foy, Québec, Canada.
Occup Med (Lond). 2006 Jun;56(4):282-3. doi: 10.1093/occmed/kql007.
Algae powders have been increasingly used in therapeutic preparations. Their potential as inducers of occupational asthma (OA), however, remains to be demonstrated.
A 33-year-old woman developed asthma following exposure to algae powder used for thalassotherapy. She had positive patch tests to nickel and cobalt in an evaluation for intermittent skin rash. At work, she had a normal forced expiratory flow in 1 s (FEV(1)) but moderate airway hyperresponsiveness. Bronchial provocation tests (BPT) were obtained.
On BPT, an isolated early response was observed after a 1-min inhalation of dry algae powder, with a 50% fall in FEV(1) after exposure; the control BPT with lactose powder was negative.
We report a case of algae-powder-induced OA. Such responses could be due to a sensitization to algae proteins or metal contaminants bioabsorbed by the vegetal particles.
藻类粉末在治疗制剂中的应用日益广泛。然而，其作为职业性哮喘（OA）诱导剂的潜力仍有待证实。
一名33岁女性在接触用于海水浴疗法的藻类粉末后患上哮喘。在对间歇性皮疹进行评估时，她对镍和钴的斑贴试验呈阳性。工作时，她的一秒用力呼气量（FEV₁）正常，但气道反应性中度增高。进行了支气管激发试验（BPT）。
在BPT中，吸入干燥藻类粉末1分钟后观察到孤立的早期反应，暴露后FEV₁下降50%；乳糖粉末对照BPT为阴性。
我们报告一例藻类粉末诱发的OA病例。此类反应可能是由于对藻类蛋白或植物颗粒生物吸收的金属污染物致敏所致。
