Woliński Jarosław, Zabielski Romuald
Zakład Fizjologii Przewodu Pokarmowego, Instytut Fizjologii i Zywienia Zwierzat im. Jana Kielanowskiego, Polska Akademia Nauk, ul. Instytucka 3, 05-110 Jabłonna, Poland.
Med Wieku Rozwoj. 2005 Oct-Dec;9(4):629-36.
Leptin is a 167-amino acid protein, involved in the regulation of adipose tissue, food intake and body weight in humans and animals. Recently, leptin synthesis has been found in the placenta and mammary glands in human and numerous animal species suggesting a role in controlling growth of the foetus and neonate. Colostrum and milk contain high amounts of leptin, in particular during the first few days of lactation. Milk leptin is associated with milk fats what may affect the results of analysis. In humans, a correlation was found between the milk leptin and plasma leptin, body weight and body mass index. In sows, no correlation have been found between the concentration of leptin in blood plasma and milk during the first week of lactation. Milk replacer formulas contain less leptin and leptin supplementation reverses the negative influence of formula feeding on the functional development of the gastro-intestinal tract in neonatal piglets. Data obtained so far suggest that breast milk leptin may control the gut development in newborns.
瘦素是一种由167个氨基酸组成的蛋白质，参与调节人类和动物的脂肪组织、食物摄入及体重。最近发现，在人类和众多动物物种的胎盘及乳腺中存在瘦素合成现象，这表明瘦素在控制胎儿和新生儿生长方面发挥作用。初乳和乳汁中含有大量瘦素，尤其是在哺乳的头几天。乳汁中的瘦素与乳脂相关，这可能会影响分析结果。在人类中，发现乳汁瘦素与血浆瘦素、体重及体重指数之间存在相关性。在母猪中，哺乳期第一周血浆和乳汁中的瘦素浓度之间未发现相关性。代乳品配方中瘦素含量较低，补充瘦素可逆转代乳品喂养对新生仔猪胃肠道功能发育的负面影响。目前获得的数据表明，母乳中的瘦素可能控制新生儿肠道发育。
