Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland.
Anim Sci J. 2014 Feb;85(2):143-9. doi: 10.1111/asj.12099. Epub 2013 Aug 1.
Radioimmunology was used to determine leptin and ghrelin levels in sow colostrum and milk in relation to those in sow and neonatal pig blood plasma and to the body weight of piglets during the first week of lactation. The highest concentration of leptin was found in colostrum on the second day of lactation (69.3 ± 6.3 ng/mL). Leptin concentrations in sow plasma were significantly lower than in colostrum/milk (2.19 ± 0.9 ng/mL, P = 0.7692) and were stable in the first 7 days of lactation. Total and active ghrelin concentrations in colostrum/milk were stable in the measured time points (6734 ± 261 pg/mL, P = 0.3397; 831 ± 242 pg/mL, P = 0.3988, respectively). Total ghrelin concentrations in sow plasma were lower than in colostrum/milk. These results indicate that pigs follow a unique species-specific pattern of leptin and ghrelin synthesis, release and existence, and that the mammary gland is an important source of leptin and ghrelin contained in colostrum/milk.
放射免疫学法被用于确定母猪初乳和乳汁中瘦素和胃饥饿素的水平，以及这些水平与母猪和新生仔猪血浆中的水平以及哺乳期第一周仔猪体重的关系。在哺乳期的第二天，初乳中发现的瘦素浓度最高（69.3±6.3ng/mL）。母猪血浆中的瘦素浓度明显低于初乳/乳汁（2.19±0.9ng/mL，P=0.7692），并且在哺乳期的前 7 天保持稳定。初乳/乳汁中的总和活性胃饥饿素浓度在测量的时间点保持稳定（6734±261pg/mL，P=0.3397；831±242pg/mL，P=0.3988）。母猪血浆中的总胃饥饿素浓度低于初乳/乳汁。这些结果表明，猪遵循一种独特的物种特异性瘦素和胃饥饿素合成、释放和存在模式，乳腺是初乳/乳汁中所含瘦素和胃饥饿素的重要来源。
