Quaye Isaac K, Ababio Grace, Amoah Albert G
Department of Medical Biochemistry, University of Ghana Medical School, Korle-Bu, Ghana.
J Atheroscler Thromb. 2006 Apr;13(2):90-4. doi: 10.5551/jat.13.90.
We have investigated the role of haptoglobin gene polymorphisms in 129 type 2 diabetic patients and 87 non-diabetic subjects, classified by the ADA criteria, in Ghana. The diabetic subjects were recruited consecutively from the National Diabetic Management and Research Center of the University of Ghana Medical School, Korle-Bu, Accra, Ghana and were categorized by their haptoglobin phenotypes. The haptoglobin 2 allele was determined to be a risk factor for type 2 diabetes in Ghana (OR = 6.1, 95% CI = 1.8-21.2; P = .0.001) while the Hp1 allele appeared protective (OR = 0.56, 95% CI = 0.31-1.0; P = .06). The deleterious role of the Hp2 allele was further evidenced by the reduced risk associated with Hp2-1M mutant heterozygotes, who produce less Hp2 protein than the normal Hp2-1 heterozygote. (OR = 0.52, 95% CI = 0.27-1.0; P = 0.06). The subjects with the homozygous Hp2 allele were also hypertensive and overweight. There was no difference (p > 0.05) in the levels of triglycerides, total cholesterol, LDL and HDL between diabetic subjects with different haptoglobin phenotypes. We conclude that hypertensive and overweight individuals with the Hp2-2 phenotype in Ghana are at a high risk of developing type 2 diabetes and may require a more aggressive management.
我们在加纳对129名2型糖尿病患者和87名非糖尿病受试者（根据美国糖尿病协会标准分类）进行了研究，以探讨触珠蛋白基因多态性的作用。糖尿病受试者是从加纳大学医学院科勒 - 布教学医院（位于加纳阿克拉）的国家糖尿病管理与研究中心连续招募的，并根据其触珠蛋白表型进行分类。在加纳，触珠蛋白2等位基因被确定为2型糖尿病的一个风险因素（比值比=6.1，95%置信区间=1.8 - 21.2；P = 0.001），而触珠蛋白1等位基因似乎具有保护作用（比值比=0.56，95%置信区间=0.31 - 1.0；P = 0.06）。与正常的Hp2 - 1杂合子相比，产生较少Hp2蛋白的Hp2 - 1M突变杂合子相关风险降低，这进一步证明了Hp2等位基因的有害作用（比值比=0.52，95%置信区间=0.27 - 1.0；P = 0.06）。具有纯合Hp2等位基因的受试者也患有高血压和超重。不同触珠蛋白表型的糖尿病受试者在甘油三酯、总胆固醇、低密度脂蛋白和高密度脂蛋白水平上没有差异（P>0.05）。我们得出结论，加纳具有Hp2 - 2表型的高血压和超重个体患2型糖尿病的风险很高，可能需要更积极的管理。
