Second Department of Medicine, University of Debrecen, Debrecen, Hungary.
Hum Immunol. 2011 Apr;72(4):348-54. doi: 10.1016/j.humimm.2011.01.008. Epub 2011 Jan 21.
The α-chain alleles 1 and 2 of haptoglobin (Hp) molecule account for three phenotypes, which have biologically important differences in their antioxidant, scavenging, and immunomodulatory properties and may thereby influence the course of inflammatory diseases. A follow-up observational study was conducted to assess the association between haptoglobin phenotype and the development of clinically significant bacterial infections in patients with liver cirrhosis. Sera of 336 patients with liver cirrhosis of various etiologies and 384 healthy subjects were investigated. Haptoglobin phenotypes were determined by gel electrophoresis and assigned corresponding genotype. Haptoglobin phenotype distributions of patients and controls was similar (Hp1-1: 10.7% vs 11.5%, Hp2-1: 47.9% vs 46.1% and Hp2-2: 41.4% vs 42.4%). The probability of clinically significant bacterial infections was calculated for each haptoglobin phenotype (Hp1-1: 50.0%, Hp2-1: 36.0% and Hp2-2: 26.6%, p = 0.039). In a logistic regression analysis, Hp1-1 phenotype (p = 0.015, OR: 2.74, 95% CI: 1.22-6.13), Child-Pugh stage (p = 0.038, OR: 1.40, 95% CI: 1.02-1.91) and presence of co-morbidities (p < 0.001, OR: 2.64, 95% CI: 1.63-4.27) were independently associated with infections. In a Cox regression analysis, Hp1-1 phenotype (p = 0.014), Child-Pugh stage C (p < 0.001), and presence of co-morbidities (p = 0.004) were associated with time to first infectious episode. Phenotypic haptoglobin polymorphism was independent predictor for risk and time to first clinically significant bacterial infectious episode.
血红蛋白（Hp）分子的α-链等位基因 1 和 2 导致三种表型，它们在抗氧化、清除和免疫调节特性方面具有重要的生物学差异，并且可能影响炎症性疾病的病程。进行了一项随访观察性研究，以评估血红蛋白表型与肝硬化患者发生临床显著细菌感染的关系。研究了来自不同病因的 336 例肝硬化患者和 384 例健康对照者的血清。通过凝胶电泳确定血红蛋白表型，并分配相应的基因型。患者和对照组的血红蛋白表型分布相似（Hp1-1：10.7% vs 11.5%，Hp2-1：47.9% vs 46.1%和 Hp2-2：41.4% vs 42.4%）。计算了每种血红蛋白表型的临床显著细菌感染概率（Hp1-1：50.0%，Hp2-1：36.0%和 Hp2-2：26.6%，p = 0.039）。在逻辑回归分析中，Hp1-1 表型（p = 0.015，OR：2.74，95%CI：1.22-6.13），Child-Pugh 分期（p = 0.038，OR：1.40，95%CI：1.02-1.91）和合并症的存在（p < 0.001，OR：2.64，95%CI：1.63-4.27）与感染独立相关。在 Cox 回归分析中，Hp1-1 表型（p = 0.014），Child-Pugh 分期 C（p < 0.001）和合并症的存在（p = 0.004）与首次感染发作的时间相关。表型血红蛋白多态性是发生首次临床显著细菌性感染的独立预测因子。
