Ferchichi L, Chadli-Debbiche A, Koubâa W, Khayat O, Labbène N, Ben Gamra O, Khedim A, Ben Ayed M
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Habib Thameur, 8 Rue Ali Ben Ayed Montfleury, 1008 Tunis, Tunisie.
J Mal Vasc. 2006 May;31(2):85-7. doi: 10.1016/s0398-0499(06)76524-6.
Mucormycosis is caused by a zygomycetes fungus in a vascular location. This fungus is a saprophytic organism which can become pathogenic in specific conditions, particularly in patients with diabetes mellitus. A rhinocerebral localization is common, leading to often fatal devastating sinusitis. Positive diagnosis requires histological proof with characteristic hyphal tissue invasion. Frozen section is essential for diagnosis and management of rhinocerebral mucormycosis.
We report four cases of rhinocerebral mucormycosis in diabetic patients, two men and two women, mean age 51 years.
Histological examination showed characteristic hyphae in a vascular localization. Treatment was systemic antifungal therapy with amphotericin B and debridement of necrotic tissue. Three patients recovered completely. One died.
Rhinocerebral mucormycosis is a rare fungal infection with very poor prognosis. The aim of this study was to report the clinical and pathological features of rhinocerebral mucormycosis and to evaluate the contribution of frozen section for diagnosis and management.
毛霉病由血管部位的接合菌纲真菌引起。这种真菌是一种腐生生物，在特定条件下可致病，尤其是在糖尿病患者中。鼻脑部位受累很常见，常导致致命性的严重鼻窦炎。确诊需要组织学证据，显示特征性的菌丝组织侵袭。冰冻切片对于鼻脑型毛霉病的诊断和治疗至关重要。
我们报告了4例糖尿病患者的鼻脑型毛霉病病例，2名男性和2名女性，平均年龄51岁。
组织学检查显示血管部位有特征性菌丝。治疗方法为使用两性霉素B进行全身抗真菌治疗以及清除坏死组织。3例患者完全康复。1例死亡。
鼻脑型毛霉病是一种罕见的真菌感染，预后很差。本研究的目的是报告鼻脑型毛霉病的临床和病理特征，并评估冰冻切片对诊断和治疗的作用。
