用于高效递送小干扰RNA（siRNA）和强效基因沉默的聚酰胺-胺（PAMAM）树枝状大分子。
PAMAM dendrimers for efficient siRNA delivery and potent gene silencing.
作者信息
Zhou Jiehua, Wu Jiangyu, Hafdi Nadia, Behr Jean-Paul, Erbacher Patrick, Peng Ling
机构信息
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
出版信息
Chem Commun (Camb). 2006 Jun 14(22):2362-4. doi: 10.1039/b601381c. Epub 2006 May 10.
DOI:10.1039/b601381c
PMID:16733580
Abstract
Genuine, nondegraded PAMAM dendrimers self-assemble with siRNA into nanoscale particles that are efficient for siRNA delivery and induce potent endogenous gene silencing.
摘要
纯正、未降解的聚酰胺-胺（PAMAM）树枝状大分子与小干扰RNA（siRNA）自组装形成纳米级颗粒，这些颗粒在siRNA递送方面效率很高，并能诱导有效的内源性基因沉默。
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