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两种新型非病毒基因递送载体：由（2-羟丙基）-β-环糊精或（2-羟丙基）-γ-环糊精交联的低分子量聚乙烯亚胺

Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin.

作者信息

Huang Hongliang, Tang Guping, Wang Qingqing, Li Da, Shen Fenping, Zhou Jun, Yu Hai

机构信息

Institute of Immunology, Zhejiang University, Hangzhou 310031, PR China.

出版信息

Chem Commun (Camb). 2006 Jun 14(22):2382-4. doi: 10.1039/b601130f. Epub 2006 Mar 22.

DOI:10.1039/b601130f
PMID:16733587
Abstract

Two novel polymers of low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin showed lower cytotoxicity and higher transfection efficiency for the delivery of plasmid DNA compared with those of polyethylenimine (PEI, 25 kDa).

摘要

与聚乙烯亚胺（PEI，25 kDa）相比，两种由（2-羟丙基）-β-环糊精或（2-羟丙基）-γ-环糊精交联的新型低分子量聚乙烯亚胺聚合物在递送质粒DNA时表现出更低的细胞毒性和更高的转染效率。

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