Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
Adv Drug Deliv Rev. 2013 Aug;65(9):1215-33. doi: 10.1016/j.addr.2013.05.001. Epub 2013 May 11.
The excellent biocompatibility and unique inclusion capability as well as powerful functionalization capacity of cyclodextrins and their derivatives make them especially attractive for engineering novel functional materials for biomedical applications. There has been increasing interest recently to fabricate supramolecular systems for drug and gene delivery based on cyclodextrin materials. This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery. First, we introduce cyclodextrin materials utilized for self-assembly. The fabrication technologies of supramolecular systems including nanoplatforms and hydrogels as well as their applications in nanomedicine and pharmaceutical sciences are then highlighted. At the end, the future directions of this field are discussed.
环糊精及其衍生物具有优异的生物相容性和独特的包合能力，以及强大的功能化能力，这使得它们特别适合用于医学应用的新型功能材料的工程设计。最近，人们越来越感兴趣地基于环糊精材料构建用于药物和基因传递的超分子系统。这篇综述重点介绍了基于环糊精的组装体的构建及其在控制药物传递中的应用的最新进展和最新技术。首先，我们介绍了用于自组装的环糊精材料。然后强调了包括纳米平台和水凝胶在内的超分子体系的构建技术及其在纳米医学和药物科学中的应用。最后，讨论了该领域的未来发展方向。
