Wang Hong-wei, Wang Jia-bi, Liu Yue-hua, Zuo Ya-gang, Jin Hong-zhong, Jiang Guo-tiao, Li Hong-chun, Ma Dong-lai
Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Apr;28(2):202-5.
To evaluate the clinical efficacy and safety of Q-switched Alexandrite laser in the treatment of pigmentary skin, diseases ( PSDs).
Totally 4 656 patients with PSDs were treated with Q-switched Alexandrite laser. These PDSs included nevus of Ota, seborrheic keratosis, tattoo, naevus fusco-caeruleus zygomaticus, cafe-au-lait-spots, lentigo, naevus of Ito, and spilus naevus. The outcomes and adverse events after treatment were oberserved.
The response rate was 92.31% and the cure rate was 55.39% for nevus of Ota after six times of treatment, and the cure rate was 100% after nine times of treatment. The response rate was 100% for freckles, seborrheic keratosis, and naevus fuscocaeruleus zygomaticus after four times of treatment. The response rate was more than 77.18% and the cure rate was more than 50% for tattoos after three times of treatment, including amateur tattoo, artificial eyebrow, eyelid lines, and traumatic tattoo. However, after four times of treatment, the response rate and the cure rate were only 50. 00% and 21.43% for cafe-au-lait spots, and 50.00% and 25.00% for spilus naevus, respectively. The response rate was 35.29% for lentigo and 25.00% for naevus of Ito/ spilus naevus after four times of treatment.
Q-switched Alexandrite laser is effective in the treatment of nevus of Ota, seborrheic keratosis, tattoo, and naevus fusco-caeruleus zygomaticus, but has limited efficacy for cafe-au-lait-spots, lentigo, naevus of Ito, and spilus naevus.
评估调Q紫翠宝石激光治疗色素性皮肤病（PSDs）的临床疗效及安全性。
共4656例色素性皮肤病患者接受调Q紫翠宝石激光治疗。这些色素性皮肤病包括太田痣、脂溢性角化病、纹身、颧部褐青色痣、咖啡斑、雀斑样痣、伊藤痣及斑痣。观察治疗后的疗效及不良事件。
太田痣经6次治疗后有效率为92.31%，治愈率为55.39%，经9次治疗后治愈率为100%。雀斑、脂溢性角化病及颧部褐青色痣经4次治疗后有效率为100%。纹身（包括业余纹身、纹眉、纹眼线及外伤性纹身）经3次治疗后有效率超过77.18%，治愈率超过50%。然而，咖啡斑及斑痣经4次治疗后有效率分别仅为50.00%和50.00%，治愈率分别为21.43%和25.00%。雀斑样痣经4次治疗后有效率为35.29%，伊藤痣/斑痣经4次治疗后有效率为25.00%。
调Q紫翠宝石激光治疗太田痣、脂溢性角化病、纹身及颧部褐青色痣有效，但对咖啡斑、雀斑样痣、伊藤痣及斑痣疗效有限。
