[闪光灯泵浦脉冲染料激光（585纳米）治疗葡萄酒色斑——对2317例中国患者的回顾性研究]

[Flashlamp-pumped pulsed dye laser (585 nm) in the treatment of port-wine stains--a retrospective study of 2317 Chinese patients].

作者信息

Zuo Ya-gang, Wang Jia-bi, Jiang Guo-tiao, Liu Yue-hua, Jin Hong-zhong, Wang Hong-wei, Ma Dong-lai, Li Hong-chun

机构信息

Department of Dermnnatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Apr;28(2):206-9.

PMID:16733905

Abstract

OBJECTIVE

To evaluate the efficacy and safety of 585 nm flashlamp-pumped pulsed dye lasers (PDL) in the treatment of port-wine stains (PWS).

METHODS

A retrospective review was performed in 2 317 patients with PWS who visited the Dermatology Laser Centre of PUMC Hospital and accepted treatment with 585 nm PDL. The correlation between the treatment efficacy and the treatment sessions, lesion types, and usage of other therapies were analyzed. The adverse effects were also observed.

RESULTS

All the 2 317 patients with PWS received 1-13 consecutive treatments with PDL at 2-3-month intervals. The median number of treatment was 4.93 and the median energy density was 8.29 J/cm2. The response rate after 8 treatments sessions were 84%. The response rate in patients whose lesions are characterized as purple plaques with proliferation and treated with isotope, CO2, cryotherapy, and other treatments was significantly lower than the total response rate (P < 0.05). Superficial scar, hyperpigmentation, and hypopigmentation were found in 5.2%, 2.5%, and 4.0% of these patients, respectively.

CONCLUSION

585 nm PDL is effective and safe in treating PWS.

摘要

目的

评估585nm闪光灯泵浦脉冲染料激光（PDL）治疗鲜红斑痣（PWS）的疗效和安全性。

方法

对2317例到中国医学科学院北京协和医院皮肤科激光中心就诊并接受585nm PDL治疗的PWS患者进行回顾性分析。分析治疗疗效与治疗次数、皮损类型及其他治疗方法使用情况之间的相关性，并观察不良反应。

结果

2317例PWS患者均接受了1至13次连续的PDL治疗，治疗间隔为2至3个月。治疗次数中位数为4.93次，能量密度中位数为8.29J/cm²。8次治疗后的有效率为84%。皮损表现为紫红色增生性斑块且接受过同位素、CO2、冷冻治疗及其他治疗的患者有效率显著低于总有效率（P<0.05）。这些患者中分别有5.2%、2.5%和4.0%出现浅表瘢痕、色素沉着和色素减退。