Drost Wm Tod, Couto C Guillermo, Fischetti Anthony J, Mattoon John S, Iazbik Cristina
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
J Vet Intern Med. 2006 May-Jun;20(3):544-6. doi: 10.1892/0891-6640(2006)20[544:cogfrb]2.0.co;2.
Greyhounds have significantly higher serum creatinine (SCr) concentration than do non-Greyhound dogs that may be attributable to differences in glomerular filtration rate (GFR). By means of plasma clearance of technetium Tc 99m diethylenetriaminepentaacetic acid, GFR was measured in 10 Greyhounds and 10 non-Greyhound dogs with normal findings of physical examination, CBC, serum biochemical analysis, and urinalysis. Dogs were fed the same diet for a minimum of 6 weeks before GFR data collection. Greyhounds had significantly higher mean +/- SD GFR (3.0 +/- 0.1 vs 2.5 +/- 0.2 ml/min/ kg; P = .01) and SCr concentration (1.8 +/- 0.1 vs 1.5 +/- 0.1 mg/dL; P = .03) than did non-Greyhound dogs, but the serum urea nitrogen (SUN) concentration was not significantly different (18 +/- 1 vs 18 +/- 2 mg/dL; P = .8). Therefore, the higher SCr concentration in Greyhounds is not attributable to decreased GFR, and may be associated with the high muscle mass in the breed. Healthy Greyhounds have higher GFR than do non-Greyhound dogs.
灵缇犬的血清肌酐（SCr）浓度显著高于非灵缇犬，这可能归因于肾小球滤过率（GFR）的差异。通过锝 Tc 99m 二乙三胺五乙酸的血浆清除率，对 10 只灵缇犬和 10 只非灵缇犬进行了 GFR 测量，这些犬的体格检查、全血细胞计数、血清生化分析和尿液分析结果均正常。在收集 GFR 数据前，犬只至少 6 周喂食相同的饮食。灵缇犬的平均±标准差 GFR（3.0±0.1 对比 2.5±0.2 ml/min/kg；P = 0.01）和 SCr 浓度（1.8±0.1 对比 1.5±0.1 mg/dL；P = 0.03）显著高于非灵缇犬，但血清尿素氮（SUN）浓度无显著差异（18±1 对比 18±2 mg/dL；P = 0.8）。因此，灵缇犬较高的 SCr 浓度并非归因于 GFR 降低，可能与该品种较高的肌肉量有关。健康的灵缇犬比非灵缇犬具有更高的 GFR。
