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Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei.在缺乏Argonaute1的布氏锥虫中,表达位点沉默和生命周期进程看起来正常。
Mol Biochem Parasitol. 2006 Sep;149(1):102-107. doi: 10.1016/j.molbiopara.2006.04.005. Epub 2006 May 12.
2
Regulation of antigen gene expression in Trypanosoma brucei.布氏锥虫中抗原基因表达的调控
Trends Parasitol. 2005 Nov;21(11):517-20. doi: 10.1016/j.pt.2005.08.016. Epub 2005 Aug 29.
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Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma brucei.布氏锥虫中单个循环后期变异表面糖蛋白基因的同步表达。
Mol Biochem Parasitol. 2015 Mar-Apr;200(1-2):1-4. doi: 10.1016/j.molbiopara.2015.04.001. Epub 2015 Apr 18.
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Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome.化学抑制昆虫期非洲锥虫的溴结构域蛋白会扰乱变体表面糖蛋白库的沉默,并导致转录组广泛变化。
Microbiol Spectr. 2023 Jun 15;11(3):e0014723. doi: 10.1128/spectrum.00147-23. Epub 2023 Apr 25.
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Insights into the regulation of GPEET procyclin during differentiation from early to late procyclic forms of Trypanosoma brucei.布氏锥虫从早期前循环型向晚期前循环型分化过程中GPEET前环素调控机制的研究进展
Mol Biochem Parasitol. 2013 Oct;191(2):66-74. doi: 10.1016/j.molbiopara.2013.09.004. Epub 2013 Sep 27.
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Expression-site-associated-gene-8 (ESAG8) is not required for regulation of the VSG expression site in Trypanosoma brucei.布氏锥虫中VSG表达位点的调控不需要表达位点相关基因8(ESAG8)。
Mol Biochem Parasitol. 2001 Oct;117(2):211-5. doi: 10.1016/s0166-6851(01)00341-3.
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ESAG11, a new VSG expression site-associated gene from Trypanosoma brucei.ESAG11,一种来自布氏锥虫的新的VSG表达位点相关基因。
Mol Biochem Parasitol. 2000 Nov;111(1):223-8. doi: 10.1016/s0166-6851(00)00305-4.
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Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity.布氏锥虫 Tim50 具有 PAP 活性,在细胞周期调控和寄生虫感染力中发挥关键作用。
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TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomes.TelAP1 将端粒复合物与非洲锥虫发育表达位点沉默联系起来。
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Expression and function of surface proteins in Trypanosoma brucei.布氏锥虫表面蛋白的表达与功能
Mol Biochem Parasitol. 1998 Mar 1;91(1):3-36. doi: 10.1016/s0166-6851(97)00183-7.

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TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomes.TelAP1 将端粒复合物与非洲锥虫发育表达位点沉默联系起来。
Nucleic Acids Res. 2018 Apr 6;46(6):2820-2833. doi: 10.1093/nar/gky028.
2
Expression of the RNA-binding protein RBP10 promotes the bloodstream-form differentiation state in Trypanosoma brucei.RNA结合蛋白RBP10的表达促进了布氏锥虫的血流型分化状态。
PLoS Pathog. 2017 Aug 11;13(8):e1006560. doi: 10.1371/journal.ppat.1006560. eCollection 2017 Aug.
3
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.VEX1控制锥虫抗原变异所需的等位基因排斥。
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7225-30. doi: 10.1073/pnas.1600344113. Epub 2016 May 25.
4
The CAF1-NOT complex of trypanosomes.锥虫的CAF1-NOT复合体
Front Genet. 2014 Jan 2;4:299. doi: 10.3389/fgene.2013.00299.
5
Comparative transcriptome analysis of small noncoding RNAs in different stages of Trypanosoma brucei.比较不同发育阶段布氏锥虫小非编码 RNA 的转录组分析。
RNA. 2013 Jul;19(7):863-75. doi: 10.1261/rna.035683.112. Epub 2013 May 23.
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PRMT1 methylates the single Argonaute of Toxoplasma gondii and is important for the recruitment of Tudor nuclease for target RNA cleavage by antisense guide RNA.PRMT1 甲基化刚地弓形虫的单个 Argonaute,并对于招募 Tudor 核酸内切酶用于反义向导 RNA 对靶 RNA 的切割很重要。
Cell Microbiol. 2012 Jun;14(6):882-901. doi: 10.1111/j.1462-5822.2012.01763.x. Epub 2012 Feb 28.
7
The cell biology of Trypanosoma brucei differentiation.布氏锥虫分化的细胞生物学
Curr Opin Microbiol. 2007 Dec;10(6):539-46. doi: 10.1016/j.mib.2007.09.014. Epub 2007 Nov 9.
8
Depletion of newly synthesized Argonaute1 impairs the RNAi response in Trypanosoma brucei.新合成的AGO1蛋白的缺失会损害布氏锥虫中的RNA干扰反应。
RNA. 2007 Jul;13(7):1132-9. doi: 10.1261/rna.474707. Epub 2007 May 25.
9
Introducing histone modification in trypanosomes.介绍锥虫中的组蛋白修饰。
Trends Parasitol. 2007 Jun;23(6):239-42. doi: 10.1016/j.pt.2007.03.009. Epub 2007 Apr 11.
10
Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei: evidence for genome-wide conservation of life-cycle stage-specific regulatory elements.布氏锥虫核编码细胞色素氧化酶亚基的转录后调控:全基因组生命周期阶段特异性调控元件保守性的证据
Nucleic Acids Res. 2006;34(18):5312-24. doi: 10.1093/nar/gkl598. Epub 2006 Sep 29.

本文引用的文献

1
Slicer function of Drosophila Argonautes and its involvement in RISC formation.果蝇AGO蛋白的切割功能及其在RISC形成中的作用
Genes Dev. 2005 Dec 1;19(23):2837-48. doi: 10.1101/gad.1370605. Epub 2005 Nov 14.
2
Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs.拟南芥AGO1是一种RNA切割酶,可选择性招募微小RNA和小干扰RNA。
Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11928-33. doi: 10.1073/pnas.0505461102. Epub 2005 Aug 4.
3
The role of the RNAi machinery in heterochromatin formation.RNA干扰机制在异染色质形成中的作用。
Cell. 2005 Jul 15;122(1):13-6. doi: 10.1016/j.cell.2005.06.034.
4
Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline.AGO蛋白PIWI控制果蝇雄性生殖系中逆转录转座子的移动。
Nucleic Acids Res. 2005 Apr 7;33(6):2052-9. doi: 10.1093/nar/gki323. Print 2005.
5
Purified Argonaute2 and an siRNA form recombinant human RISC.纯化的 Argonaute2 与一种小干扰 RNA 形成重组人 RNA 诱导沉默复合体。
Nat Struct Mol Biol. 2005 Apr;12(4):340-9. doi: 10.1038/nsmb918. Epub 2005 Mar 30.
6
Perspective: machines for RNAi.观点:RNA干扰机器
Genes Dev. 2005 Mar 1;19(5):517-29. doi: 10.1101/gad.1284105.
7
The developmental cell biology of Trypanosoma brucei.布氏锥虫的发育细胞生物学
J Cell Sci. 2005 Jan 15;118(Pt 2):283-90. doi: 10.1242/jcs.01649.
8
Selection and characterization of RNA interference-deficient trypanosomes impaired in target mRNA degradation.在靶mRNA降解中受损的RNA干扰缺陷型锥虫的筛选与鉴定
Eukaryot Cell. 2004 Dec;3(6):1445-53. doi: 10.1128/EC.3.6.1445-1453.2004.
9
Function of the Trypanosome Argonaute 1 protein in RNA interference requires the N-terminal RGG domain and arginine 735 in the Piwi domain.锥虫AGO1蛋白在RNA干扰中的功能需要N端RGG结构域和Piwi结构域中的精氨酸735。
J Biol Chem. 2004 Nov 26;279(48):49889-93. doi: 10.1074/jbc.M409280200. Epub 2004 Sep 21.
10
RNA silencing in plants.植物中的RNA沉默
Nature. 2004 Sep 16;431(7006):356-63. doi: 10.1038/nature02874.

Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei.

作者信息

Janzen Christian J, van Deursen Frederick, Shi Huafang, Cross George A M, Matthews Keith R, Ullu Elisabetta

机构信息

Laboratory of Molecular Parasitology, The Rockefeller University, Box 185, 1230 York Avenue, New York, NY 10021-6399, USA.

Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK.

出版信息

Mol Biochem Parasitol. 2006 Sep;149(1):102-107. doi: 10.1016/j.molbiopara.2006.04.005. Epub 2006 May 12.

DOI:10.1016/j.molbiopara.2006.04.005
PMID:16735068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3904126/
Abstract
摘要