Fenn Katelyn, Matthews Keith R
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK.
Curr Opin Microbiol. 2007 Dec;10(6):539-46. doi: 10.1016/j.mib.2007.09.014. Epub 2007 Nov 9.
Developmental events in the life-cycle of the sleeping sickness parasite comprise integrated changes in cell morphology, metabolism, gene expression and signalling pathways. In each case these processes differ from the eukaryotic norm. In the past three years, understanding of these developmental processes has progressed from a description of the cytological events of differentiation to a discovery of its underlying molecular controls. With an expanding set of reagents for the identification of distinct parasite life-cycle stages in the tsetse, trypanosome differentiation is being studied from the molecular to the organismal and population level. Interestingly, the new molecular discoveries provide insights into the biology of the parasite in the field.
昏睡病寄生虫生命周期中的发育事件包括细胞形态、代谢、基因表达和信号通路的综合变化。在每种情况下，这些过程都不同于真核生物的常态。在过去三年中，对这些发育过程的理解已从对分化细胞学事件的描述发展到对其潜在分子控制的发现。随着用于鉴定采采蝇体内不同寄生虫生命周期阶段的试剂不断增加，锥虫分化正从分子水平到生物体和种群水平进行研究。有趣的是，新的分子发现为该寄生虫在野外的生物学特性提供了见解。
