Hui Pui Wah, Lee Chin Peng, Tang Mary Hoi Yin, Ho Pak Chung
Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong.
Curr Opin Obstet Gynecol. 2006 Jun;18(3):319-24. doi: 10.1097/01.gco.0000193005.42910.35.
Nuchal translucency is one of the important markers in the first trimester during antenatal screening for fetal Down's syndrome. With the observation of alterations in biochemical markers in pregnancies conceived after assisted reproduction, this review presents current information related to the thickness of nuchal translucency in these pregnancies.
Early small studies did not demonstrate any discrepancy in the thickness of nuchal translucency in fetuses from assisted reproduction and from spontaneous pregnancies, but there has been recent evidence to suggest an increased level of nuchal translucency in singletons from various modes of assisted-reproduction technology. Nuchal translucency in twins following assisted reproduction did not, however, show a similar increase. Although the effect of chorionicity was not specifically addressed, nuchal translucency thickness in twins born after assisted reproduction was reported to be comparable to that in spontaneous singletons. It is possible that singletons and twins after assisted reproduction exhibit different antenatal behavior and pregnancy courses.
Similar to other biochemical markers of fetal Down's syndrome, nuchal translucency is increased in singletons after assisted-reproduction technology. Further studies on twin pregnancies, in particular dichorionic twins, are necessary before conclusive evidence can be drawn for multiple pregnancies.
颈部半透明厚度是孕早期胎儿唐氏综合征产前筛查的重要指标之一。随着辅助生殖技术受孕妊娠中生化指标变化的观察，本综述呈现了这些妊娠中颈部半透明厚度的相关最新信息。
早期小型研究未显示辅助生殖胎儿与自然受孕胎儿的颈部半透明厚度有任何差异，但最近有证据表明，来自各种辅助生殖技术的单胎妊娠中颈部半透明厚度有所增加。然而，辅助生殖后的双胎妊娠颈部半透明厚度并未出现类似增加。尽管未特别探讨绒毛膜性的影响，但据报道，辅助生殖后出生的双胎颈部半透明厚度与自然受孕单胎相当。辅助生殖后的单胎和双胎可能表现出不同的产前行为和妊娠过程。
与胎儿唐氏综合征的其他生化指标类似，辅助生殖技术后的单胎妊娠颈部半透明厚度增加。在得出多胎妊娠的确切证据之前，有必要对双胎妊娠，尤其是双绒毛膜双胎进行进一步研究。
