Hui P W, Tang M H Y, Ng E H Y, Yeung W S B, Ho P C
Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong.
Prenat Diagn. 2006 Jun;26(6):510-3. doi: 10.1002/pd.1445.
As opposed to biochemical markers of Down syndrome, nuchal translucency (NT) was once thought to be a more reliable screening marker for high order multiple pregnancies and pregnancies conceived after assisted conception. Recent data suggested that NT in singleton fetuses from assisted reproduction technology (ART) was thicker than those from singleton pregnancies. The present study compared the thickness of NT in dichorionic twins from natural conception and assisted reproduction.
A retrospective analysis for comparison of NT thickness on 3319 spontaneous singletons, 19 pairs of spontaneous twins and 27 pairs of assisted reproduction twins was performed.
The median NT multiple of median (MoM) of spontaneous singletons was 1.00. For twins, the median NT MoM for pregnancies after assisted reproduction and natural conception were 1.02 and 1.07 respectively. There was no statistical difference in the NT thickness among the three pregnancy groups.
Contrary to the observed increase in NT in singleton pregnancies from assisted reproduction, the NT in dichorionic twins was comparable to the spontaneous ones. The mode of conception appears to impose differential influence on singletons and twins.
与唐氏综合征的生化标志物不同，颈部透明带（NT）曾被认为是高阶多胎妊娠及辅助受孕后妊娠更可靠的筛查标志物。近期数据表明，辅助生殖技术（ART）单胎胎儿的NT比自然单胎妊娠胎儿的NT更厚。本研究比较了自然受孕双绒毛膜双胎和辅助生殖双绒毛膜双胎的NT厚度。
对3319例自然单胎、19对自然双胎和27对辅助生殖双胎的NT厚度进行回顾性分析比较。
自然单胎的NT中位数倍数（MoM）为1.00。对于双胎，辅助生殖后妊娠和自然受孕妊娠的NT MoM中位数分别为1.02和1.07。三组妊娠组的NT厚度无统计学差异。
与辅助生殖单胎妊娠中观察到的NT增加相反，双绒毛膜双胎的NT与自然受孕双胎相当。受孕方式似乎对单胎和双胎有不同影响。
