Brambilla Elisabeth, Lantuejoul Sylvie
Département d'Anatomie et Cytologie Pathologiques, CHU Grenoble, France.
Ann Pathol. 2005 Dec;25(6):529-44. doi: 10.1016/s0242-6498(05)86165-6.
Neuroendocrine pulmonary and thymic tumors constitute a distinct category of tumors collectively disclosing morphologic and biologic neuroendocrine features. They are classified in 4 histopathological types and 3 malignancy grades. The typical carcinoids are of low grade, the atypical carcinoids of intermediate grade and the large cell neuroendocrine carcinoma with the small cell carcinoma are high grade neuroendocrine tumors. Their distinction relies on objective morphologic and phenotypic criteria of strong clinical significance and predictive prognostic value.
神经内分泌性肺和胸腺肿瘤构成了一类独特的肿瘤，共同呈现出形态学和生物学上的神经内分泌特征。它们分为4种组织病理学类型和3个恶性等级。典型类癌为低级别，非典型类癌为中级别，大细胞神经内分泌癌和小细胞癌为高级别神经内分泌肿瘤。它们的区分依赖于具有重要临床意义和预测预后价值的客观形态学和表型标准。
