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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Woollen B H, Hart T B, Batten P L, Laird W J, Davies D S, Dollery C T

ICI Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK.

Hum Exp Toxicol. 1991 Jan;10(1):39-43. doi: 10.1177/096032719101000107.

Fluazifop-butyl, the active ingredient of FUSILADE, a selective herbicide, was administered orally to three male volunteers at a dose level of 0.07 mg kg-1 body weight. Over a period of 6 d between 80 and 93% of the dose was excreted in urine as the metabolite fluazifop, the majority within the first 24 h. Peak plasma concentrations of fluazifop occurred 1-2.5 h after administration. 2. The elimination of fluazifop from plasma and urine can be described by a one-compartment pharmacokinetic model and the elimination half-life was estimated from blood and urine data to be within the range 9-37 h. Fluazifop was found to bind to serum proteins. 3. The study indicates that the amount of fluazifop-butyl absorbed in exposed persons can be assessed by measuring fluazifop concentrations in urine.

精稳杀得（FUSILADE）是一种选择性除草剂，其活性成分氟吡甲禾灵以0.07毫克/千克体重的剂量水平口服给予三名男性志愿者。在6天的时间里，80%至93%的剂量以代谢物氟吡甲禾灵的形式随尿液排出，大部分在最初24小时内排出。氟吡甲禾灵的血浆浓度峰值在给药后1至2.5小时出现。2. 氟吡甲禾灵从血浆和尿液中的消除可用单室药代动力学模型描述，根据血液和尿液数据估计消除半衰期在9至37小时范围内。发现氟吡甲禾灵与血清蛋白结合。3. 该研究表明，通过测量尿液中氟吡甲禾灵的浓度，可以评估接触者体内吸收的氟吡甲禾灵丁酯的量。

Woollen B H, Hart T B, Batten P L, Laird W J, Davies D S, Dollery C T

ICI Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK.

Hum Exp Toxicol. 1991 Jan;10(1):39-43. doi: 10.1177/096032719101000107.

Fluazifop-butyl, the active ingredient of FUSILADE, a selective herbicide, was administered orally to three male volunteers at a dose level of 0.07 mg kg-1 body weight. Over a period of 6 d between 80 and 93% of the dose was excreted in urine as the metabolite fluazifop, the majority within the first 24 h. Peak plasma concentrations of fluazifop occurred 1-2.5 h after administration. 2. The elimination of fluazifop from plasma and urine can be described by a one-compartment pharmacokinetic model and the elimination half-life was estimated from blood and urine data to be within the range 9-37 h. Fluazifop was found to bind to serum proteins. 3. The study indicates that the amount of fluazifop-butyl absorbed in exposed persons can be assessed by measuring fluazifop concentrations in urine.

精稳杀得（FUSILADE）是一种选择性除草剂，其活性成分氟吡甲禾灵以0.07毫克/千克体重的剂量水平口服给予三名男性志愿者。在6天的时间里，80%至93%的剂量以代谢物氟吡甲禾灵的形式随尿液排出，大部分在最初24小时内排出。氟吡甲禾灵的血浆浓度峰值在给药后1至2.5小时出现。2. 氟吡甲禾灵从血浆和尿液中的消除可用单室药代动力学模型描述，根据血液和尿液数据估计消除半衰期在9至37小时范围内。发现氟吡甲禾灵与血清蛋白结合。3. 该研究表明，通过测量尿液中氟吡甲禾灵的浓度，可以评估接触者体内吸收的氟吡甲禾灵丁酯的量。