Kanematsu S, Ishii S, Umino A, Fujihira T, Kashiwa A, Yamamoto N, Kurumaji A, Nishikawa T
Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
J Neural Transm (Vienna). 2006 Nov;113(11):1717-21. doi: 10.1007/s00702-006-0517-3. Epub 2006 Jun 1.
The continuous intra-cortical infusion of a glia toxin, fluorocitrate, at the concentration of 1 mM caused a decrease in the cortical extracellular contents of an intrinsic coagonist for the N-methyl-D-aspartate (NMDA) type glutamate receptor, D-serine, by peaking at 40 min by -25% but produced an increase in those of glycine and L-serine. The attenuated glial activity by fluorocitrate was verified by a marked reduction in the extracellular glutamine contents. The present findings suggest that a group of glial cells such as a population of the protoplasmic astrocytes could, at least in part, participate differently in the regulation of the extracellular release of D-serine and another NMDA coagonist glycine in the medial frontal cortex of the rat.
以1 mM的浓度持续向皮质内注入神经胶质毒素氟代柠檬酸，导致N-甲基-D-天冬氨酸（NMDA）型谷氨酸受体的内源性协同激动剂D-丝氨酸的皮质细胞外含量在40分钟时达到峰值，下降了25%，但甘氨酸和L-丝氨酸的含量却有所增加。细胞外谷氨酰胺含量的显著降低证实了氟代柠檬酸对神经胶质活性的减弱作用。目前的研究结果表明，一组神经胶质细胞，如原浆性星形胶质细胞群体，至少在一定程度上可能以不同方式参与大鼠内侧前额叶皮质中D-丝氨酸和另一种NMDA协同激动剂甘氨酸的细胞外释放调节。
