Leygraf A, Hohoff C, Freitag C, Willis-Owen S A G, Krakowitzky P, Fritze J, Franke P, Bandelow B, Fimmers R, Flint J, Deckert J
Laboratory of Molecular Psychiatry, Department of Psychiatry, University of Münster, Münster, Germany.
J Neural Transm (Vienna). 2006 Dec;113(12):1921-5. doi: 10.1007/s00702-006-0484-8. Epub 2006 Jun 1.
Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p = 0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p = 0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.
Rgs2（G蛋白信号调节因子2）基因最近被报道为小鼠焦虑行为的数量性状基因，雄性Rgs2基因敲除小鼠已被证明比野生型小鼠更焦虑。因此，我们在173名患有惊恐障碍的患者和173名匹配的德国血统对照样本中研究了四个非编码单核苷酸多态性。在基因型水平上，所有四个单核苷酸多态性均与惊恐障碍相关（p = 0.02 - 0.05）。在单倍型水平上，观察到包含SNP3和SNP4的单倍型有最强的相关性（亚组男性和患有广场恐惧症的男性：p = 0.01和0.03）。这表明该基因3'端存在功能性多态性。我们的结果支持这样的假设，即Rgs2基因的变异在人类焦虑症的发生中也起作用。
