Henderson R A, Lane S, Henry J A
Guy's Hospital, London, UK.
Hum Exp Toxicol. 1991 Jan;10(1):59-62. doi: 10.1177/096032719101000110.
A 48-year-old woman developed QT prolongation and episodes of life-threatening ventricular tachycardia (torsades de pointes) after intentional overdose of haloperidol and orphenadrine. The arrhythmia did not respond to conventional anti-arrhythmic therapy but was suppressed by atrial overdrive pacing. A literature review identified haloperidol as the most likely cause of the torsades de pointes.
