Department of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Am J Emerg Med. 2010 Jan;28(1):95-102. doi: 10.1016/j.ajem.2008.09.029.
Drug-induced prolongation of the QT interval is frequently encountered after medication overdose. Such toxicity can result in degeneration to torsades de pointes (TdP) and require overdrive pacing. We present 3 cases in which intentional medication overdose resulted in QTc prolongation with subsequent degeneration to TdP. Despite appropriate care, including magnesium therapy, each case required overdrive pacing for resolution of TdP. Although rarely encountered, patients with drug-induced TdP can be successfully managed with overdrive pacing.
药物过量后，经常会出现药物引起的 QT 间期延长。这种毒性可能导致尖端扭转型室性心动过速（TdP），需要超速起搏。我们介绍了 3 例因药物过量导致 QTc 延长，随后发展为 TdP 的病例。尽管给予了适当的治疗，包括镁治疗，但每例患者都需要超速起搏来解决 TdP。虽然很少见，但药物引起的 TdP 患者可以通过超速起搏成功治疗。
