Tant L, Steinfeld S
Service de Rhumatologie, Hôpital Erasme.
Rev Med Brux. 2006 Mar-Apr;27(2):95-8.
Rheumatoid arthritis is an auto-immune disorder which diagnosis is based on clinical, radiological and biological criteria. Disease progression is characterized by appearance of bone erosions and progressive articular deformations which attenuate functional mobility. Only rheumatoid factor is actually considered as biological factor among recognized diagnostical criteria despite its weak sensibility and specificity rates. Anti-cyclic citrullinated peptides antibodies are directed toward citrullinated isoforms of some filaggrin's epitopes. Their sensitivity and specificity reach respectively 80 and 99%. Their presence is correlated to disease activity and to bone erosions development. They allow early identification and treatment of rheumatoid arthritis affected patients which is actually considered as a priority.
类风湿性关节炎是一种自身免疫性疾病，其诊断基于临床、放射学和生物学标准。疾病进展的特征是出现骨侵蚀和进行性关节变形，这会削弱功能活动能力。在公认的诊断标准中，尽管类风湿因子的敏感性和特异性较低，但实际上它是唯一被视为生物学因素的指标。抗环瓜氨酸肽抗体针对某些丝聚蛋白表位的瓜氨酸化异构体。它们的敏感性和特异性分别达到80%和99%。它们的存在与疾病活动以及骨侵蚀的发展相关。它们有助于早期识别和治疗类风湿性关节炎患者，而这实际上被视为首要任务。
