Krsek M, Rosická M, Haluzík M, Papezová H, Krízová J, Justová V, Lacinová Z, Jarkovská Z
III. interní klinika 1. lékarské fakulty UK a VFN, Praha.
Vnitr Lek. 2002 Oct;48(10):948-51.
Ghrelin is recently discovered peptide hormone involved in the regulation of growth hormone secretion as well as in the regulation of food intake and energetic homeostasis. The study was aimed to describe the changes in ghrelin serum levels in patients with anorexia nervosa and its relationship to some other studied parameters. Sixteen women patients with anorexia nervosa and thirteen healthy women of comparable age were examined clinically and blood samples were taken for estimation of serum levels of ghrelin, leptin, soluble leptin receptor, IGF-I, IGFBP-1 and IGFBP-3. Ghrelin serum levels were significantly increased in the group of patients with anorexia nervosa (p < 0,05). In contrary, serum leptin levels were decreased in the group of patients with anorexia nervosa (p < 0,01). Serum ghrelin levels did not correlate with any other of studied parameters with exception of BMI. We can conclude that serum ghrelin levels are increased in patients with anorexia nervosa and their increase fails to significantly stimulate food intake in this group of patients.
胃饥饿素是最近发现的一种肽类激素，参与生长激素分泌的调节以及食物摄入和能量稳态的调节。本研究旨在描述神经性厌食症患者血清胃饥饿素水平的变化及其与其他一些研究参数的关系。对16名神经性厌食症女性患者和13名年龄相仿的健康女性进行了临床检查，并采集血样以测定血清胃饥饿素、瘦素、可溶性瘦素受体、胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子结合蛋白-1（IGFBP-1）和胰岛素样生长因子结合蛋白-3（IGFBP-3）的水平。神经性厌食症患者组的血清胃饥饿素水平显著升高（p < 0.05）。相反，神经性厌食症患者组的血清瘦素水平降低（p < 0.01）。血清胃饥饿素水平除了与体重指数（BMI）外，与其他任何研究参数均无相关性。我们可以得出结论，神经性厌食症患者的血清胃饥饿素水平升高，且这种升高未能显著刺激该组患者的食物摄入。
