Krsek M, Rosická M, Papezová H, Krízová J, Kotrlíková E, Haluz'k M, Justová V, Lacinová Z, Jarkovská Z
3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague 2, Czech Republic.
Eat Weight Disord. 2003 Sep;8(3):207-11. doi: 10.1007/BF03325015.
Ghrelin is a peptide hormone that is involved in regulating growth hormone secretion as well as food intake and energy homeostasis. The aim of this study was to compare changes in plasma ghrelin levels in patients with malnutrition due to anorexia nervosa (AN) or short bowel syndrome (SBS). Blood samples for laboratory analyses were taken from 16 AN patients (plus 13 comparable healthy controls) and 27 SBS patients (plus 13 comparable healthy controls) after an overnight fast. In comparison with their respective control groups, plasma ghrelin levels were increased in the AN patients (p < 0.05) and significantly decreased in the patients with SBS (p < 0.01). These results suggest that quantitative ghrelin secretion in the gut wall is important in determining ghrelin concentrations in the systemic circulation.
胃饥饿素是一种肽类激素，参与调节生长激素分泌以及食物摄入和能量平衡。本研究的目的是比较神经性厌食症（AN）或短肠综合征（SBS）所致营养不良患者血浆胃饥饿素水平的变化。在禁食过夜后，采集了16例AN患者（加13例匹配的健康对照）和27例SBS患者（加13例匹配的健康对照）的血样进行实验室分析。与各自的对照组相比，AN患者的血浆胃饥饿素水平升高（p < 0.05），而SBS患者的血浆胃饥饿素水平显著降低（p < 0.01）。这些结果表明，肠壁中胃饥饿素的定量分泌对于确定体循环中胃饥饿素的浓度很重要。
