Soria J C, Fizazi K, Merad M, Le Chevalier T
Département de médecine, institut Gustave-Roussy, Villejuif, France.
Bull Cancer. 1996 Aug;83(8):605-8.
We report the case of a female patient who developed a second contralateral small cell lung carcinoma (SCLC) five years after a right upper lobe SCLC treated by sequential chemotherapy and chest radiation therapy. This second primary neoplasia was revealed by an isolated and symptomatic syndrome of inappropriate antidiuretic hormone secretion. Specific evolution of long-term survivors after SCLC are discussed, including consequences of combined radiochemotherapy and poor prognosis associated with persistence of tobacco smoking exposure.
我们报告了一例女性患者的病例,该患者在接受序贯化疗和胸部放射治疗的右上叶小细胞肺癌(SCLC)五年后,对侧又发生了一例小细胞肺癌。这例第二原发性肿瘤是由孤立的、有症状的抗利尿激素分泌不当综合征所揭示的。文中讨论了小细胞肺癌长期存活者的具体病情发展,包括放化疗联合治疗的后果以及与持续接触烟草烟雾相关的不良预后。