Hafizi Sassan, Dahlbäck Björn
Department of Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital Malmö, SE-205 02 Malmö, Sweden.
Cytokine Growth Factor Rev. 2006 Aug;17(4):295-304. doi: 10.1016/j.cytogfr.2006.04.004. Epub 2006 Jun 5.
The related Axl, Sky and Mer receptor tyrosine kinases (RTKs) are increasingly being implicated in a host of discrete cellular responses including cell survival, proliferation, migration and phagocytosis. Furthermore, their ligands Gas6 and protein S are characteristically dependent on vitamin K for expression of their functions. The Gas6/Axl system is implicated in several types of human cancer as well as inflammatory, autoimmune, vascular and kidney diseases. Each member of the Axl RTK subfamily possesses distinct expression profiles as well as discrete functions. In this article, we review the knowledge so far on the intracellular signalling interactions and pathways concerning each of the Axl RTKs. In this way, we hope to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions.
相关的Axl、Sky和Mer受体酪氨酸激酶（RTK）越来越多地参与一系列不同的细胞反应，包括细胞存活、增殖、迁移和吞噬作用。此外，它们的配体Gas6和蛋白S的功能表达典型地依赖于维生素K。Gas6/Axl系统与几种类型的人类癌症以及炎症、自身免疫、血管和肾脏疾病有关。Axl RTK亚家族的每个成员都具有独特的表达谱以及不同的功能。在本文中，我们回顾了迄今为止关于每个Axl RTK的细胞内信号相互作用和途径的知识。通过这种方式，我们希望更深入地了解将它们区分开来并传递其相关功能的机制。
