环境湿度会影响极早产儿皮肤屏障的成熟速率。
Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants.
作者信息
Agren Johan, Sjörs Gunnar, Sedin Gunnar
机构信息
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
出版信息
J Pediatr. 2006 May;148(5):613-7. doi: 10.1016/j.jpeds.2005.11.027.
OBJECTIVES
To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might influence their postnatal skin maturation.
STUDY DESIGN
In 22 preterm infants (GA 23-27 weeks), transepidermal water loss (TEWL) was determined at postnatal ages (PNA) of 0, 3, 7, 14, and 28 days. At a PNA of 7 days, the infants were randomized to care at either 50% or 75% RH.
RESULTS
TEWL decreased at a slower rate in infants nursed at the higher RH. At a PNA of 28 days, TEWL was about twice as high in infants nursed at 75% RH (22 +/- 2 g/m2 h) than in those nursed at 50% RH (13 +/- 1 g/m2 h; P < .001).
CONCLUSIONS
The results indicate that the level of RH influences skin barrier development, with more rapid barrier formation in infants nursed at a lower RH. The findings have an impact on strategies for promoting skin barrier integrity in extremely preterm infants.
目的
检验以下假设，即护理早产儿的相对湿度（RH）水平可能会影响其出生后皮肤的成熟。
研究设计
对22例早产儿（孕龄23 - 27周）在出生后0、3、7、14和28天测定经表皮水分流失（TEWL）。在出生后7天时，将婴儿随机分为在50%或75%相对湿度环境下护理。
结果
在较高相对湿度环境下护理的婴儿，TEWL下降速度较慢。在出生后28天时，在75%相对湿度环境下护理的婴儿的TEWL（22±2 g/m²·h）约为在50%相对湿度环境下护理的婴儿（13±1 g/m²·h）的两倍（P <.001）。
结论
结果表明，相对湿度水平会影响皮肤屏障的发育，在较低相对湿度环境下护理的婴儿皮肤屏障形成更快。这些发现对促进极早产儿皮肤屏障完整性的策略具有影响。
Zotero 插件