Csokmay John M, Frattarelli John L
Tripler Army Medical Center, Honolulu, Hawaii 95859-5000, USA.
Obstet Gynecol. 2006 Jun;107(6):1292-6. doi: 10.1097/01.AOG.0000217695.95139.1e.
To evaluate the effect of simple basal ovarian cysts in patients undergoing infertility treatment with clomiphene citrate. To evaluate the effect of clomiphene citrate on pretreatment simple ovarian cysts.
Prospective cohort trial of 84 infertility patients undergoing ovulation induction with clomiphene citrate. Patients with basal ovarian cysts of 10 mm or greater (n = 42) were compared with patients without ovarian cysts (n = 42). The main outcome measure was ovulation determined by menstrual cycle day 21 progesterone level. Each patients with an ovarian cyst was also evaluated for persistence or resolution of the cyst in association with ovulation and cyst size. Pretreatment and posttreatment transvaginal ultrasound examinations were performed on all patients.
Demographic data were similar among the groups. The mean ovarian cyst size was 17.4 +/- 5.8 mm. Patients in the ovarian cyst group were significantly less likely to ovulate (80.9% versus 97.6%, P < .05), but did not differ in pregnancy rate compared with patients without baseline ovarian cysts (4.8% versus 11.9%, P = .43). Persistent ovarian cysts occurred in 36.7% of the patients. The initial size of the cyst did not predict cyst persistence.
According to these data, basal ovarian cysts significantly reduce ovulatory events in patients treated with clomiphene citrate.
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评估单纯性基础卵巢囊肿对接受枸橼酸氯米芬治疗的不孕症患者的影响。评估枸橼酸氯米芬对治疗前单纯性卵巢囊肿的影响。
对84例接受枸橼酸氯米芬促排卵治疗的不孕症患者进行前瞻性队列试验。将基础卵巢囊肿直径达10毫米或更大的患者（n = 42）与无卵巢囊肿的患者（n = 42）进行比较。主要观察指标是根据月经周期第21天的孕酮水平确定是否排卵。还对每例有卵巢囊肿的患者评估囊肿在排卵及囊肿大小方面的持续存在或消退情况。对所有患者进行治疗前和治疗后的经阴道超声检查。
各组间人口统计学数据相似。卵巢囊肿平均大小为17.4 +/- 5.8毫米。卵巢囊肿组患者排卵的可能性显著较低（80.9%对97.6%，P <.05），但与无基线卵巢囊肿的患者相比，妊娠率无差异（4.8%对11.9%，P = 0.43）。36.7%的患者出现持续性卵巢囊肿。囊肿的初始大小不能预测囊肿是否持续存在。
根据这些数据，基础卵巢囊肿显著降低了接受枸橼酸氯米芬治疗患者的排卵几率。
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