KPC Medical College, Kolkata, India.
Arch Gynecol Obstet. 2012 Mar;285(3):873-7. doi: 10.1007/s00404-011-2091-7. Epub 2011 Oct 7.
The objective of this study was to compare the efficacy of letrozole versus clomiphene citrate as an ovulation induction drug in polycystic ovarian syndrome (PCOS) patients of Indian origin.
One hundred and forty seven infertile PCOS patients were randomly given letrozole (2.5 mg) (n = 69) or clomiphene (100 mg) (n = 78) from day 3 to day 7 of menstrual cycle, followed-up with transvaginal serial folliculometry from day 9. 10,000 IU of human chorionic gonadotropin (hCG) was administered when at least 1 ovarian follicle was ≥ 18 mm in size.
The pertinent results of the study are as follows: on the day of hCG injection, mean E2 level was significantly higher in the clomphene citrate group (817 ± 286.70 pg/ml) in comparison with letrozole group (444.03 ± 85.42 pg/ml). Mean endometrial development was 8.72 ± 1.41 mm in the letrozole and 8.78 ± 1.16 mm in the clomiphene group (P = 0.004).
Letrozole has beneficial effect on endometrium, thereby potentially increasing pregnancy rates after successful ovulation induction in women with PCOS.
本研究旨在比较来曲唑与枸橼酸氯米酚作为排卵诱导药物在印度来源的多囊卵巢综合征（PCOS）患者中的疗效。
147 名不孕的 PCOS 患者随机给予来曲唑（2.5mg）（n=69）或枸橼酸氯米酚（100mg）（n=78），从月经周期的第 3 天至第 7 天开始，随后从第 9 天开始经阴道进行连续卵泡测量。当至少有 1 个卵巢卵泡≥18mm 时，给予 10000IU 人绒毛膜促性腺激素（hCG）。
研究的相关结果如下：在 hCG 注射日，枸橼酸氯米酚组（817±286.70pg/ml）的平均 E2 水平明显高于来曲唑组（444.03±85.42pg/ml）。来曲唑组的平均子宫内膜发育为 8.72±1.41mm，枸橼酸氯米酚组为 8.78±1.16mm（P=0.004）。
来曲唑对子宫内膜有有益的影响，从而可能增加 PCOS 妇女成功排卵诱导后的妊娠率。
