Spauwen Janneke, Krabbendam Lydia, Lieb Roselind, Wittchen Hans-Ulrich, van Os Jim
Department of Psychiatry and Neuropsychology, Maastricht University, PO Box 616 (DRT 10), 6200 MD Maastricht, The Netherlands.
Br J Psychiatry. 2006 Jun;188:527-33. doi: 10.1192/bjp.bp.105.011346.
The reported link between psychological trauma and onset of psychosis remains controversial.
To examine associations between self-reported psychological trauma and psychotic symptoms as a function of prior evidence of vulnerability to psychosis (psychosis proneness).
At baseline, 2524 adolescents aged 14-24 years provided self-reports on psychological trauma and psychosis proneness, and at follow-up (on average 42 months later) participants were interviewed for presence of psychotic symptoms.
Self-reported trauma was associated with psychotic symptoms, in particular at more severe levels (adjusted OR 1.89, 95% CI1.16-3.08) and following trauma associated with intense fear, helplessness or horror. The risk difference between those with and without self-reported trauma at baseline was 7% in the group with baseline psychosis proneness, but only 1.8% in those without (adjusted test for difference between these two effect sizes: chi2=4.6, P=0.032).
Exposure to psychological trauma may increase the risk of psychotic symptoms in people vulnerable to psychosis.
心理创伤与精神病发作之间的报道联系仍存在争议。
根据先前易患精神病（精神病倾向）的证据，研究自我报告的心理创伤与精神病症状之间的关联。
在基线时，2524名14 - 24岁的青少年提供了关于心理创伤和精神病倾向的自我报告，在随访时（平均42个月后）对参与者进行访谈，了解是否存在精神病症状。
自我报告的创伤与精神病症状相关，尤其是在更严重的程度上（调整后的比值比为1.89，95%置信区间为1.16 - 3.08）以及与强烈恐惧、无助或恐惧相关的创伤之后。在基线时有精神病倾向的组中，基线时自我报告有创伤和无创伤者之间的风险差异为7%，但在无基线精神病倾向的组中仅为1.8%（这两种效应大小差异的调整检验：卡方 = 4.6，P = 0.032）。
暴露于心理创伤可能会增加易患精神病者出现精神病症状的风险。
