Price Eroston A, Schueler Harold, Perper Joshua A
Broward County Medical Examiner's Office, Fort Lauderdale, Florida, USA.
Am J Forensic Med Pathol. 2006 Jun;27(2):97-102. doi: 10.1097/01.paf.0000188072.04746.d5.
Subcutaneous injections of inert or quasi-inert plastic material designed to smooth out wrinkled skin or to create a more esthetically sought appearance have become very popular with the American public in general, and, in particular, with certain groups highly focused on their physical image. The case of the injection procedure has attracted into the field of plastic medicine a substantial number of illegal, incompetent, and unscrupulous operators. Their ignorance of involved medical risks and procedures not uncommonly results in severe complications, disfigurement, and death of patients. We report the typical pathological and chemical findings of a systemic fatal silicone embolism in a 53-year-old heterosexual woman following illegal chronic injections of silicone in her hips and buttocks. The injected subcutaneous silicone apparently migrated rapidly from the interstitial subcutaneous tissue into the general blood stream resulting in a fatal systemic silicone embolism. An analysis of the presented case in conjunction with a review of the pertinent medical literature, including a recent article, revealed a marked similarity in the clinicopathologic findings between silicone embolism and fat embolism.
皮下注射惰性或准惰性塑料材料以抚平皱纹皮肤或塑造更美观的外观，这一做法在广大美国公众中，尤其是在某些高度关注自身形象的群体中非常流行。注射程序的情况吸引了大量非法、不称职且不择手段的从业者进入整形医学领域。他们对相关医疗风险和程序的无知常常导致患者出现严重并发症、毁容甚至死亡。我们报告了一名53岁异性恋女性在臀部非法长期注射硅胶后发生系统性致命硅酮栓塞的典型病理和化学发现。注射的皮下硅酮显然从皮下间质组织迅速迁移到全身血流中，导致致命的系统性硅酮栓塞。结合对相关医学文献（包括最近一篇文章）的回顾对该病例进行分析后发现，硅酮栓塞和脂肪栓塞的临床病理表现存在显著相似性。
