Khalifa A Ben, Najjar M, Addad F, Turki E, Mghirbi T
Department of Forensic Medicine, University Hospital of Monastir, Monastir, Tunisia.
Am J Forensic Med Pathol. 2006 Jun;27(2):175-7. doi: 10.1097/01.paf.0000221070.02753.6e.
To evaluate the effectiveness of the increase of postmortem cardiac troponin T (cTn T) in acute disease-related deaths.
Peripheral venous blood was sampled from 39 autopsies performed. Thirty nonhemolyzed specimens were considered in the final analysis (n = 30).Only the calculation of the cTn T was performed using the Roche Diagnostics Elecsys 2010 Immunoassay System. The high limit and the cutoff are 25 ng/mL. Deaths were divided into 2 groups, according to sudden cardiac deaths (group 1, n = 15) and non-cardiac-related deaths without resuscitation (group 2, n = 15).
All the cases with visual myocardial infarction had elevated concentrations of cTn T. The difference of the postmortem cTn T concentrations between resuscitated and nonresuscitated is nonsignificant. In the non-cardiac-related deaths, the elevated concentrations of cTn T were only noted in all cases of electrocution.
In clinical practice, several biochemical markers are used for the diagnosis of myocardial infarction. Because of its extreme specificity for myocardial damage, cTn T and cardiac troponin I (cTn I) are frequently used. The results of these assays could then be used to facilitate selection for cases that may be released following histologic examinations.
评估急性疾病相关死亡中死后心肌肌钙蛋白T（cTnT）升高的有效性。
从39例尸检中采集外周静脉血。最终分析纳入30份未溶血标本（n = 30）。仅使用罗氏诊断Elecsys 2010免疫分析系统进行cTnT的计算。高限和临界值为25 ng/mL。根据心源性猝死（第1组，n = 15）和未复苏的非心脏相关死亡（第2组，n = 15）将死亡分为2组。
所有肉眼可见心肌梗死的病例cTnT浓度均升高。复苏和未复苏病例的死后cTnT浓度差异无统计学意义。在非心脏相关死亡中，仅在所有触电死亡病例中发现cTnT浓度升高。
在临床实践中，多种生化标志物用于诊断心肌梗死。由于cTnT和心肌肌钙蛋白I（cTnI）对心肌损伤具有极高的特异性，因此经常使用。这些检测结果可用于协助选择可能在组织学检查后放行的病例。
