Panchal B C, Trippodo N C
Department of Pharmacology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000.
Cardiovasc Res. 1993 Dec;27(12):2264-9. doi: 10.1093/cvr/27.12.2264.
The recently developed BIO T0-2 strain of cardiomyopathic hamster shows a uniform pathogenesis of dilated cardiomyopathy and represents a useful model of congestive heart failure. Although used in biochemical studies, BIO T0-2 animals have not been characterised by haemodynamic measurements. The aim was to compare the systemic and the regional haemodynamic variables in conscious BIO T0-2 animals at a stage of compensated heart failure with those of age matched normal hamsters of BIO F1B designation.
Hamsters were studied at 8-10 months of age, a stage at which the BIO T0-2 animals have been found to have non-oedematous heart failure. Catheters were implanted in normal and cardiomyopathic hamsters. Following a 3 h recovery, systemic and regional haemodynamic variables were measured with pressure transducers and radioactive microspheres.
BIO T0-2 hamsters had lower (p < 0.05) mean arterial pressure [83(SEM 3) v 126(2) mm Hg] and cardiac index [205(19) v 338(25) ml.min-1.kg-1], and higher (p < 0.05) left ventricular end diastolic pressure [21(1) v 4(1) mm Hg] and total peripheral resistance index [30(4) v 15(2) mm Hg.min.ml-1.kg-1] than BIO F1B animals. Blood flows to the heart and kidneys were less (p < 0.05) in BIO T0-2 than in BIO F1B animals.
The haemodynamic profile in the BIO T0-2 strain of cardiomyopathic hamsters is characterised by low cardiac output, increased preload, and reduced renal blood flow, and resembles that in many patients with congestive heart failure.
最近培育出的心肌病仓鼠BIO T0 - 2品系表现出扩张型心肌病的一致发病机制，是充血性心力衰竭的有用模型。尽管已用于生化研究，但尚未通过血流动力学测量对BIO T0 - 2动物进行表征。目的是比较处于代偿性心力衰竭阶段的清醒BIO T0 - 2动物与年龄匹配的BIO F1B品系正常仓鼠的全身和局部血流动力学变量。
在8 - 10月龄时对仓鼠进行研究，此阶段已发现BIO T0 - 2动物患有非水肿性心力衰竭。将导管植入正常和患心肌病的仓鼠体内。经过3小时恢复后，用压力传感器和放射性微球测量全身和局部血流动力学变量。
与BIO F1B动物相比，BIO T0 - 2仓鼠的平均动脉压较低（p < 0.05）[83（标准误3）对126（2）mmHg]、心脏指数较低（p < 0.05）[205（19）对338（25）ml·min⁻¹·kg⁻¹]，左心室舒张末期压力较高（p < 0.05）[21（1）对4（1）mmHg]，总外周阻力指数较高（p < 0.05）[30（4）对15（2）mmHg·min·ml⁻¹·kg⁻¹]。BIO T0 - 2仓鼠流向心脏和肾脏的血流量比BIO F1B动物少（p < 0.05）。
心肌病仓鼠BIO T0 - 2品系的血流动力学特征是心输出量低、前负荷增加和肾血流量减少，与许多充血性心力衰竭患者相似。
