喂食高脂饮食的大鼠和兔子血浆中的丁酰胆碱酯酶活性。

Butyrylcholinesterase activity in plasma of rats and rabbits fed high-fat diets.

Van Lith H A, Van Zutphen L F, Beynen A C

Department of Laboratory Animal Science, Veterinary Faculty, State University, Utrecht, The Netherlands.

Comp Biochem Physiol A Comp Physiol. 1991;98(2):339-42. doi: 10.1016/0300-9629(91)90543-l.

Abstract

Comparative studies with rats and rabbits were carried out to address the question as to whether the amount of dietary fat affects butyrylcholinesterase (EC 3.1.1.8.) activity in plasma. 2. Plasma butyrylcholinesterase activities were about 5-fold higher in rabbits than rats. 3. Ad libitum feeding of diets enriched with corn oil caused increased body weights in rabbits but not in rats 4. Plasma butyrylcholinesterase activities of rats were increased with increasing intakes of corn oil. In rabbits, such an effect could not be demonstrated conclusively. 5. Evidence is presented that in rats the substitution of dietary corn oil for isocaloric amounts of either carbohydrates or protein produces similar increases in plasma butyrylcholinesterase activity. 6. This suggests that among macronutrients the amount of fat primarily determines butyrylcholinesterase activity in the plasma of rats.

摘要

开展了大鼠和兔子的比较研究，以探讨膳食脂肪量是否会影响血浆中丁酰胆碱酯酶（EC 3.1.1.8.）的活性。2. 兔子血浆中的丁酰胆碱酯酶活性比大鼠高约5倍。3. 随意喂食富含玉米油的日粮会使兔子体重增加，但大鼠体重未增加。4. 大鼠血浆中的丁酰胆碱酯酶活性随玉米油摄入量的增加而升高。在兔子中，这种效果未能得到确凿证明。5. 有证据表明，在大鼠中，用等热量的碳水化合物或蛋白质替代膳食中的玉米油会使血浆丁酰胆碱酯酶活性产生类似的升高。6. 这表明，在常量营养素中，脂肪量主要决定大鼠血浆中丁酰胆碱酯酶的活性。