Prokopová D, Tesárek B, Susta A
Physiol Bohemoslov. 1975;24(3):269-73.
Nonspecific collagenolytic activity was studied in rat bones after immobilization. The left hind limb was immobilized by sectioning the sciatic nerve. Enzyme activity was determined by using synthetic pentapeptide substrate (Pz-Pro-Leu-Gly-Pro-D-Arg). After immobilization the activity of nonspecific collagenase increased and reached its maximum on the third day after the operation. The activity was decreased after one week and attained levels of control bones three weeks after sciatic nerve section.
研究了大鼠骨骼在固定后非特异性胶原酶活性。通过切断坐骨神经来固定左后肢。使用合成五肽底物（Pz-脯氨酸-亮氨酸-甘氨酸-脯氨酸-D-精氨酸）测定酶活性。固定后，非特异性胶原酶的活性增加，并在手术后第三天达到最大值。一周后活性降低，坐骨神经切断三周后达到对照骨骼的水平。
