Elander Nils, Söderkvist Peter, Fransén Karin
Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping, Sweden.
Anticancer Res. 2006 Jan-Feb;26(1B):791-5.
Matrix metalloproteinases (MMPs) are a group of matrix-degrading proteins implicated in several pathological processes, e.g., invasion and metastasis in malignant diseases such as colorectal cancer (CRC).
One hundred and twenty-seven CRC patients and 208 controls were genotyped for MMP-1, -2, -3 and -9 promoter polymorphisms. The genotyping was performed with PCR/primer-extension/DHPLC or PCR/RFLP.
The MMP-1 2G allele was significantly associated with CRC (p=0.037). No significant association between CRC and MMP-2, -3 or -9 polymorphisms was evident. The analysis of polymorphisms in the clinicopathological subgroups displayed no significant associations.
The MMP-1 promoter polymorphism seems to affect the susceptibility to CRC, while MMP-2, -3 and -9 polymorphisms appear less likely to have any impact on CRC.
基质金属蛋白酶（MMPs）是一组参与多种病理过程的基质降解蛋白，例如在诸如结直肠癌（CRC）等恶性疾病的侵袭和转移过程中发挥作用。
对127例CRC患者和208例对照进行MMP-1、-2、-3和-9启动子多态性基因分型。基因分型采用PCR/引物延伸/DHPLC或PCR/RFLP方法进行。
MMP-1 2G等位基因与CRC显著相关（p=0.037）。未发现CRC与MMP-2、-3或-9多态性之间存在显著关联。对临床病理亚组多态性的分析未显示出显著关联。
MMP-1启动子多态性似乎影响CRC易感性，而MMP-2、-3和-9多态性对CRC的影响似乎较小。
