Xp22.3 - p21.2区域12个标记位点的基因定位。
Genetic mapping of 12 marker loci in the Xp22.3-p21.2 region.
作者信息
Alitalo T, Kruse T A, Ahrens P, Albertsen H M, Eriksson A W, de la Chapelle A
机构信息
Department of Medical Genetics, University of Helsinki, Finland.
出版信息
Hum Genet. 1991 Apr;86(6):599-603. doi: 10.1007/BF00201548.
To provide a more precise genetic map of the p22.3-p21.2 region on the short arm of the human X chromosome, we performed multilocus linkage studies in an expanded database including 31 retinoschisis families and 40 normal families. Twelve loci from this region were examined. Although significant lod scores were observed between various pairs of markers by two-point linkage analysis, the confidence limits were found to be broad. The most likely gene order on the basis of multilocus analysis was Xpter-DXS89-DXS85-DXS16-(DXS207,DXS43++ +)-DXS274-(DXS41, DXS92)-ZFX-DXS164-Xcen. All other alternative orders were excluded by odds of at least 40:1.
为了提供人类X染色体短臂上p22.3 - p21.2区域更精确的遗传图谱，我们在一个扩展数据库中进行了多位点连锁研究，该数据库包括31个视网膜劈裂症家系和40个正常家系。对该区域的12个基因座进行了检测。尽管通过两点连锁分析在各对标记之间观察到了显著的lod分数，但发现置信限较宽。基于多位点分析，最可能的基因顺序是Xpter - DXS89 - DXS85 - DXS16 - (DXS207, DXS43++ +) - DXS274 - (DXS41, DXS92) - ZFX - DXS164 - Xcen。所有其他替代顺序的可能性至少为40:1而被排除。
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