Tonevitskiĭ A G, Tabak'an E A
Ross Fiziol Zh Im I M Sechenova. 2006 Mar;92(3):330-41.
Epitopic analysis of anti-beta1-adrenergic receptor autoantibodies in the serum of patients with cardiomyopathy was performed. An immunoenzyme test system for detection of autoantibodies was developed using peptide containing 26 amino acids of the second extracellular loop of the beta1-adrenergic receptor as antigen. It was demonstrated that removal of autoantibodies against beta1-adrenergic receptor in patients with cardiomyopathy by immunoadsorption and plasmapheresis metodes led to improvement of the heart pumping capacity.
对心肌病患者血清中的抗β1-肾上腺素能受体自身抗体进行了表位分析。以含有β1-肾上腺素能受体第二个细胞外环26个氨基酸的肽为抗原，开发了一种用于检测自身抗体的免疫酶检测系统。结果表明，通过免疫吸附和血浆置换法去除心肌病患者体内针对β1-肾上腺素能受体的自身抗体，可改善心脏泵血能力。
